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LeeMWangCJinSWLabrecqueMPBeischlagTVBrockmanMAet alExpression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1

3 Mechanisms underlying cell death in cardiovascular disease Cell death is a central pathological event in CVDs, contributing to the progression of conditions such as atherosclerosis, myocardial infarction, and heart failure (Figure 2) ( Figure 2 3.1 Programmed cell death in cardiovascular diseases PCD refers to tightly regulated cellular processes involving molecular pathways that orchestrate cell demise ( Apoptosis, a caspase-mediated process, is pivotal in both acute and chronic cardiovascular injury ( Autophagy is primarily a survival mechanism, but excessive autophagy contributes to cell death under stress conditions, such as hypoxia or oxidative stress ( Iron-dependent lipid peroxidation characterizes ferroptosis, which is distinct from other PCD modalities (102)

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